In 1974, Kissinger announced the “world population plan of action” under Nixon’s presidency. NSSM 200 is nothing short of an atrocious secret government document talking about the capping of the world’s population at 8 billion. This menacing declaration of genocide was official US government policy and has been declassified in part (Document link)
Mass Ivermectin Administration
According to an article from Merck, they have shipped 4 billion doses of one version of Ivermectin, Mectizan, to people of poor countries:
“The Program reaches more than 400 million people annually; over 4 billion Mectizan [Ivermectin] 3mg tablets have been shipped to endemic countries by Merck since the inception of MDP in 1987.”
According to another Merck article, they claim the total Ivermectin doses donated surpasses 4.4 Billion… with the help of a public-partnership between Merck, the Task Force for Global Health & the WHO.
Here’s a list of all the countries that receive or have received Ivermectin donations from Merck (as per Mectizan Donation Program article):
American Samoa, Angola, Benin, Brazil, Burkina, Faso, Burundi, Cambodia, Cameroon, Central African Republic, Chad, Colombia, Congo, Cook Islands, Côte d’Ivoire, Democratic Republic of the Congo, Ecuador, Egypt, Ethiopia, Fiji, Ghana, Guatemala, Guinea, Guyana, Haiti, India, Indonesia, Kenya, Kiribati, Liberia, Malawi, Malaysia, Mali, Marshall Islands, Mexico, Mozambique, Niger, Nigeria, Niue, Palau, Papua New Guinea, Senegal, Sierra Leone, South Sudan, Sri Lanka, Sudan, São Tomé and Príncipe, Tanzania, Thailand, Timor-Leste, Togo, Tuvalu, Uganda, Vanuatu, Venezuela, Vietnam, Wallis and Futuna & Yemen
In part 1 and part 2 of the Ivermectin Vs Fertility series, we looked at a number of very concerning studies showing deleterious fertility effects of ivermectin. Let’s examine 3 of these studies again:
Study 1
In a study called ‘Adverse effects of repeated doses of Ivermectin alone or with the combination of vitamin C on reproductive system of female rabbits’ by Jawad et al, researchers tested different amounts of Ivermectin and Vitamin C on rabbits and measured the number of offspring they beget.
“The results of fertility study revealed adverse effect of ivermectin therapy on fertility and block the pregnancy in all treated group except the fifth group which administered vitamin C only as compared with control group… In conclusion: Ivermectin has adverse effects on reproductive efficacy on female rabbits”
Study 2
In a study called ‘Toxicological and pathological studies of Ivermectin on male albino rats’ Elzoghby et al, researchers examined sperm count & percentage abnormal sperm of White Albino rats given ivermectin.
Sperm Count
“Significant decrease in total sperm count with significant increase in sperm abnormality was also demonstrated.”
Study 3
In a study from Nigeria entitled ‘Effects of Ivermectin therapy on the sperm functions of Nigerian onchocerciasis patients’, some very concerning findings were published.
“We observed significant reduction in the sperm counts and sperm motility of the patients tested. On the morphology there was significant increase in the number of abnormal sperm cells. This took the forms of two heads, double tails, white (albino) sperms and extraordinarily large heads. It is suspected that the above alterations in the already determined parameters of the patients’ sperm cells could only have occurred as a result of their treatment with ivermectin.”
World Bank & Ivermectin
I was able to find 2 documents from the World Bank concerning the mass Ivermectin distribution program.
UNICEF says Ivermectin was deployed in mass in Nigeria by “109,378 community-directed distributors.” In large font UNICEF emphatically quotes a Nigerian man “I wish I had this knowledge previously, especially about the medicine called Mectizan (Ivermectin). My child wouldn’t have died.” This utterance is alleged to have occurred “after attending a community outreach session run by UNICEF-trained leaders.” It goes without saying that UNICEF cannot be trusted to properly capture peoples’ sentiments in this cherry-picked quote.
UNICEF writes in the Forbes article:
“A UNICEF partner since 1991, the pharmaceutical company Merck & Co. donates Mectizan (originally known as ivermectin) to fight river blindness. Merck works with UNICEF and other organizations to distribute the drug free of charge to all who need it.”
According to an article by PostSen.com, 79.5% of Brazillians surveyed reported using Ivermectin when they had symptoms of covid in 2022. The poll was conducted by the Barcelona Global Health Institute.
The UN And Depopulation
The United Nations and the billionaire oligarchs who control them seem much more interested in reducing the future population than alleviating suffering or helping human health & well-being.
I recently put together a compilation of video clips exposing the hidden genocide from the mouths of some of the key perpetrators:
Many of these depopulation proponents are tied in closely with the United Nations.
Overlap With The Tetanus Hcg Immunocontraceptives Disguised As Vaccines
While on the topic of NSSM 200, it’s helpful to remind ourselves of the atrocities seemingly perpetrated by the WHO and UN’s UNICEF agency with sterilants in the vaccine.
Study #1: Quercetin’s Fertility Effects On Female Mice
In a 2014 paper called ‘Effects of dietary quercetin on female fertility in mice: implication of transglutaminase 2’ by Beazley & Nurminskaya (full report) researchers found a jaw-dropping 81% reduction in viable offsprings birthed from middle aged mice when the mice were dosed with quercetin at a daily dose of just 5 mg/kg body weight.
There was also a less pronounced decrease of 14% in the number of offspring of the female mice in their prime reproductive months (2-6 months).
The researchers tracked two metrics for the two treatment groups for both of the age brackets: litters per dam & pups per litter. Here is that data for the two age brackets:
This is extremely troubling when looking at the prevalence of high dose quercetin supplementing.
Also concerning is the huge 104% increase in the ovary weight in the querectin treated animals:
“Our study shows for the first time that dietary quercetin can cause reduced reproductive potential in female mice”
“In conclusion, our data support the proposition that some activities of quercetin and its metabolites may overshadow the beneficial effects of its supplementation in females of reproductive age, calling for further analysis of the clinical data to relate our findings in mice to humans”
Study #2: Quercetin’s Fertility Effects On Male Mice
In another study called ‘Quercetin impairs the reproductive potential of male mice’ by Ranawat et al (full report):
“Quercetin increased the generation of reactive oxygen species and lipid peroxidation in the testis with concomitant decrease in sperm count and motility in a dose-dependent manner.”
“Germ cell kinetic study revealed significant loss of various germ cell populations with increasing dose of quercetin.”
Look at the massive 99.9% reduction in the total motile count (a key indicator of male fertility) at 20 mg/kg quercetin:
“The present in vivo study is an extension of our previous in vitro work wherein it was found that quercetin impaired human normal sperm motility and viability (Khanduja et al., 2001). Concomitant with the results obtained in our previous study, the present study also showed a decrease in sperm motility and concentration and altered testicular histomorphology with increasing dose of quercetin.”
“We found that quercetin affects the motility of spermatozoa and that all spermatozoa were rendered immotile at higher concentrations.”
“The previous in vitro studies reported that quercetin had inhibitory effects on membrane-bound Ca2+ -ATPase, a key enzyme involved in the regulation of sperm motility (Breitbart et al., 1985; Khanduja et al., 2001). The decreased activity of this enzyme results in Ca2+ accumulation in the cells, which in turn causes blockade of the motility apparatus and a concomitant fall in motility (Breitbart et al., 1985).”
“The histomorphology demonstrated alterations in testicular morphology such as epithelial vacuolisation and atrophy in the groups exposed to quercetin. Also, a dose-dependent increase in the extent of damage caused by the bioflavonoid was observed in our mouse model.”
“It was observed that the lumen diameter increased and germ cell height decreased with increasing doses, suggestive of thinning of the germinal epithelium and disintegration of germ cells caused by the bioflavonoid.”
“The quantitative analysis of various germ cell populations revealed a decrease in the proportion of germ cells with increasing doses of quercetin, thereby highlighting extensive damage caused by the compound.”
“The testicular morphology in the high-dose group was indicative of regressive changes in the germinal epithelium and is caused by destruction and loss of the inter-cellular bridges that are essential for the process of spermatogenesis, spermiogenesis and synchronisation of germ cell maturation (Holstein & Eckmann, 1986).”
“Quercetin impairs spermatogenesis not only by acting directly on the germ cells as a pro-oxidant, but also might be directly affecting the Sertoli cell structure and functions.”
Plummeting # of Pregnancies & Offspring In Ivermectin Rabbit Study
In a study called ‘Adverse effects of repeated doses of Ivermectin alone or with the combination of vitamin C on reproductive system of female rabbits’ by Jawad et al, researchers tested different amounts of Ivermectin and Vitamin C on rabbits and measured the number of offspring they beget.
“The results of fertility study revealed adverse effect of ivermectin therapy on fertility and block the pregnancy in all treated group except the fifth group which administered vitamin C only as compared with control group… In conclusion: Ivermectin has adverse effects on reproductive efficacy on female rabbits”
A very stark, concerning dropoff in the number of pregnancies and total offspring when the Ivermectin is introduced.
Here’s the aggregate data of Ivermectin vs no Ivermectin rabbit pregnancy rates & average number of offspring:
We see a massive reduction of pregnancy rate of 100% for the first mating and 91% for the second mating in the rabbits who received any ivermectin. We also find a plummeting average for number of offspring beget: a 100% drop in the first mating and a 92% reduction in the second mating.
“Ivermectin has adverse effects on reproductive efficacy on female rabbits”
Smaller Litter Sizes & Offspring Weights in Rattus Norvegicus Exposed to Abamectin
In a study called ‘Abamectin Induced Biochemical and Histopathological Changes in the Albino Rat, Rattus Norvegicus’ (full report) by Abd-Elhady & Abou-Elghar, researchers explored the negative effects of ivermectin of male rat fertility
“Fertility was also significantly reduced in male rats ingesting abamectin in group T2. The number of offspring was significantly reduced.”
Assessment Of Abamectin’s Antifertility Effects In Male Rats
In a study called ‘Assessment of Antifertility Activities of Abamectin Pesticide in Male Rats’ by Elbetieha and Da’as (full report)
“The number of viable fetuses was significantly reduced in females mated with males that ingested abamectin at 1.87 or 2.13 mg/animal/day.”
“Significant increases in the total number of resorptions and the number of females with resorptions were observed in females mated with the exposed males at all three concentrations.”
“Testicular sperm counts and daily sperm production were significantly decreased in exposed males.”
“The results presented in this study clearly demonstrate that ingestion of abamectin for 6 weeks induced adverse effects on male fertility and reproduction.”
“Histological evaluation of the testes revealed several abnormalities including infiltration with congested blood vessels with marked hemorrhage and a significant accumulation of connective tissue surrounding the seminiferous tubules. These results strongly suggest the adverse effects of abamectin pesticide on male rat fertility.”
“The pregnancy rate and the number of viable fetuses were significantly reduced in females impregnated by abamectin-exposed male”
“Similar studies have indicated a strong link between male infertility and exposure to more than 50 pesticides including abamectin (Cox, 1996). Rats given 0.04 mg/ kg/day abamectin had increased stillbirths, decreased pup viability, decreased lactation, and decreased pup weights (US EPA, 1990).”
“Ingestion of abamectin caused a significant reduction in both epididymal and testicular sperm counts in a dose-dependent manner.”
“In summary, our results strongly suggest that exposure to the pesticide abamectin would have adverse effects on fertility and reproduction in adult male rats”
Decrease in Sperm Count & Increase In Abnormal Sperm In White Albino Rats Given Ivermectin
In a study called ‘Toxicological and pathological studies of Ivermectin on male albino rats’ Elzoghby et al, researchers examined sperm count & percentage abnormal sperm of White Albino rats given ivermectin.
Sperm Count
“Significant decrease in total sperm count with significant increase in sperm abnormality was also demonstrated.”
Sperm Abnormalities
“Various sperm abnormalities such as head, middle piece and tail abnormalities were observed in both treated groups at both 24h and 7-days post last injection. However, at 24h post last injection the degree of sperm abnormalities was significantly (P ˂0.05) higher than the control group.”
“Consequently, it could be concluded that, it is not preferable to use ivermectin particularly at double therapeutic dose mostly to breading males.”
Pathological Analysis: Study of Male & Female Fertility In Rabbit Ivermectin Recipients
In a rabbit study called ‘Pathological studies on effects of ivermectin on male and female rabbits’ by GabAllh et al. (Full study)
“Ivermectin has adverse effect on male rabbits that received either therapeutic or double therapeutic doses that varied from mild degenerative changes to complete necrosis of spermatogenic cells with complete absence of sperms. Meanwhile, female genital system was severely affected that showing severe degeneration and hemorrhage in uterus and atritic follicles and degenerated ova in ovaries. Additionally, ivermectin induced mild reversible pathological changes in parenchymatous organs of rabbits at therapeutic dose for short period of administration. Additionally, the repeated administration of either therapeutic or double therapeutic doses of ivermectin induced severe degenerative changes and necrosis in some parenchymatous organs.”
Histopathological Results
“The histopathological results revealed mild to moderate reversible degenerative changes in examined organs of male rabbits received ivermectin weekly for 4 weeks meanwhile, this degeneration become more severe and extended to complete necrosis in some organs after longer period and higher doses of ivermectin administration.”
“Pregnant females suffered from abortion in some cases with fetal death. Female genital system was severely affected that showing severe degeneration and hemorrhage in uterus as well as atritic follicles and degenerated ova in ovaries.”
“Fig.1 Testis of male rabbit received (0.8mg/kg b.wt) ivermectin for 4weeks showing presence of multiple sperm giant cells (H&E x100). Fig.2 Testes of male rabbit received (0.4mg/kg b.wt) ivermectin for 8weeks showing vacuolation in the cytoplasm of spermatogenic cells with pyknotic nucleus. H&Ex400).”
“Fig3 Epididymis of male rabbit received (0.4mg/kg b.wt) ivermectin for 8weeks showing accumulation of necrotic sperms and some of them hyalinized together with mononuclear leucocytic infiltration (blue color) in the epididymal tubules. (H&E x200).”
“Fig.13: Feti of pregnant does that received daily ivermectin at dose 0.4mg/k.g b.wt S.C and slaughtered at 28th day of pregnancy showing stunted growth. Fig.14: Ovary of pregnant does that received daily ivermectin at dose 0.4mg/k.g b.wt S.C and slaughtered at 28 th day of pregnancy showing multiple degenerated and atritic follicles scattered on the ovarian stroma (H&E x100)”
Abamectin Vs Male Fertility & Decreased Pregnancy Rates
In a study called ‘Abamectin Pesticide Exposure and Male Infertility: Human Exposure Studies Supported By Animal Studies Point Out a Considerable Relationship’ by Celik-Ozenci et al examined a very similar pesticide to Ivermectin, Abamectin.
“Abm levels in plasma, testis, liver and adipose tissues increased significantly in LTG and HTGs. Besides normal appearance, germinal epithelium revealed presence of marked depletion of germ cells and occurrence of multinucleated giant cells. Sperm motility and [Pregnancy Rates] decreased significantly in experimental group rats. High plasma Abm levels were found in infertile farmers.”
“Percentage of sperm with normal chromatin, membranous and cytoplasmic maturity and sperm motility decreased in infertile men.”
“Abm exists at high concentrations in testes of male rats and decreased Pregnancy Rates indicate a relationship between Abm and male infertility. Tubule damage and decreased sperm motility may explain this effect. Sperm motility, sperm maturity markers of farmers exposed to Abm were negatively affected. Thus, Abm exposure can contribute to male infertility.”
Ivermectin & Male Fertility in Rats: Major Hit To Sperm Metrics
In a study called ‘Effects of ivermectin and its combination with alpha lipoic acid on expression of IGFBP-3 and HSPA1 genes and male rat fertility’ by EL-Maddawy and Naby, researchers looked into Ivermectin, and changes in fertility metrics & expression of two genes in rat testis. (full report)
Rat Ivermectin Recipients Decreased Sperm Count, Sperm Motility, Living Sperm & Testosterone
“Low level of intratesticular testosterone may lead to detachment of germ cells from seminiferous epithelium and initiate germ cell apoptosis and subsequent male infertility (Lanco-Rodriguez & Martinez-Garcia, 1998)”
From the sperm count and sperm motility measurements we can approximate the drop of total motile count post-ivermectin, a key statistic for male fertility that looks at the number of viable (ie swimming sperm cells):
Microscope Images of HE Stained Rat Testes (×100 and 250 Magnification)
“Where (c) seminiferous tubules showing severe vacculation of germinal epithelium, degeneration with an absence of spermatozoa (arrows) and interstitial edema (arrowhead) and (d) showing disorganized seminiferous tubules with severe vacculation of germinal epithelium and degeneration (arrows) with interstitial edema (arrowhead)”
Ivermectin Makes Female Rats Engage In Less Sexual Behavior
In a study called ‘Ivermectin reduces sexual behavior in female rats’ by Moreira, Bernardi & Spinosa (full report) researchers found a stark decline in femal sexual behavior in rats after ivermectin dosing.
Here is a quick glossay of the terms in this paper:
Estradiol Valerate: A synthetic form of the hormone estradiol, which is a type of estrogen.
Behavior Induced by Estradiol Valerate: Refers to the actions or reactions exhibited by an animal, particularly female rats, after being treated with estradiol valerate. This hormone can induce estrous (reproductive) behaviors, affecting sexual activity.
Behavior Induced by in Estrus: Describes the behaviors, primarily related to mating and sexual receptivity, that female animals exhibit during the estrus phase of their reproductive cycle.
Lordosis: A mating posture in many female mammals, where the back is arched downward to facilitate copulation.
Lordosis Quotient: A measure used in studies to quantify the frequency of lordosis behavior in response to a male’s advances. It is typically calculated as the number of lordosis responses divided by the number of male mounting attempts.
Lordosis Intensity: Refers to the degree or strength of the lordosis posture during each occurrence. This can be measured by the angle of spinal curvature or the overall robustness of the posture in response to male advances.
Exaggerated Lordosis: This term describes an unusually pronounced or extreme lordosis posture. It might be indicative of a heightened sexual receptivity or a specific reaction to hormonal treatments like estradiol.
Female Presenting Lordosis: This term refers to the action of a female animal adopting the lordosis posture as a response to a male’s mating attempts or in anticipation of copulation.
Nigeria Study Finds Significant Reduction in Sperm Count, Sperm Motility & Bizarre Sperm Abnormalities Post-Ivermectin
In a study from Nigeria entitled ‘Effects of Ivermectin therapy on the sperm functions of Nigerian onchocerciasis patients’, some very concerning findings were published.
“We observed significant reduction in the sperm counts and sperm motility of the patients tested. On the morphology there was significant increase in the number of abnormal sperm cells. This took the forms of two heads, double tails, white (albino) sperms and extraordinarily large heads. It is suspected that the above alterations in the already determined parameters of the patients’ sperm cells could only have occurred as a result of their treatment with ivermectin.”
Sperm Count
“There was a significant drop in the sperm counts of the patients after their treatment with ivermectin” write the authors of the study.
Here is a scatter plot of the sperm count before (x axis) and after (y axis) the ivermectin dosing. Points above the line indicate a higher sperm count after the Ivermectin and points below the line indicate a lower sperm count after Ivermectin.
Here is a chart of the sperm counts pre vs post Ivermectin for the 37 trial subjects, sorted by magnitude of sperm count drop (participant ID is noted beneath columns):
Sperm Motility
The paper also states: “There was a significant drop in the sperm counts of the patients after their treatment with ivermectin. There was also a significant reduction in the motility of the cells after the treatment with ivermectin. These reductions were not concurrent, nor were they in proportion to one another.”
Sperm motility is the percentage of sperm that can swim forward. Sperm motility is important because for a sperm cell to successfully fertilize an egg it needs to be able to swim.
Here is a scatter plot of the sperm motility before (x axis) and after (y axis) the ivermectin dosing. Points above the line indicate a higher % sperm motility after the Ivermectin and points below the line indicate a lower % sperm motility after Ivermectin.
Here is a chart of the study data for pre vs post ivermectin sperm motility (Percentage of sperm that move forward) for all 37 subjects sorted with the largest drop in motility first:
Abnormality Of Sperm
“Sperm with abnormal morphology were also found to have increased after ivermectin therapy”
Here is a scatter plot of the % of sperm deemed “abnormal” before (x axis) and after (y axis) the ivermectin dosing. Points above the line indicate a higher % of abnormal sperm after the Ivermectin and points below the line indicate a lower % of abnormal sperm after Ivermectin.
Here is the data for % abnormal sperm for each of the participants before and after their ivermectin, sorted by the largest increase increase in abnormal sperm (participant # is under the columns):
The study also notes: “On the morphology there was significant increase in the number of abnormal sperm cells. This took the forms of two heads, double tails, white (albino) sperms and extraordinarily large heads.”
Motile Count
We can calculate the total motile count of each patient’s sample by multiplying the number of sperm in the sample times the percentage that were swimming properly.
Ivermectin VS Rosy Barb Fish Sperm
In a study called ‘Exposure of Rosy Barb (Puntius conchonius) Sperm to Abamectin as an In Vitro Assay of Cytotoxicity’ by Zhang et al (full report)
“This indicates that the toxicity of abamectin to rosy barb sperm is both dose dependent and exposure time dependent.”
Mouse Study Examining Altered Fertility Post-Ivermectin
In a study called ‘Effect of ivermectin on male fertility and its interaction with P-glycoprotein inhibitor (verapamil) in rats’ by El-Nahas & El-Ashmawy (full report)
While not deemed statistically significant, there is a noticeable drop in average sperm count after ivermectin to 343.3 million sperm per ml compared to the 392.3 million sperm per ml in the No-Ivermectin control group. The Ivermectin group has a 12.5% reduction in sperm concentration
Interestingly, when paired with verapamil, a drug for high blood pressure/ chest pain, there are much more significant deleterious effects in the male fertility metrics. The paper notes this may be because verapamil serves as a Pgp blocker.
“The low ivermectin toxicity has attributed to its restricted access to some tissues, especially for being a substrate of Pgp. Pgp is linked to the integrity of blood–tissue barriers, such as the blood–brain barrier, testis or placenta and a partial blockade of Pgp could be responsible for a new drug distribution in the organism with possible increases of drug rates in organs behind these barriers. Therefore, concomitant administration of substrates and Pgp inhibitors would modify drug pharmacokinetics by increased bioavailability and organ uptake”
According to various studies (see below screen shot), certain ethnicities are much more prone to a TT MDR1 gene exon 26 C3435T mutation which, according to Hitzl et al:
“Carriers homozygous for this polymorphism (TT) showed more than two-fold lower PGP expression… compared to the CC group”
Does this mean people with a TT mutation (and perhaps CT to a lesser extent) on gene exon 26 C3435T are more prone to Ivermectin toxicity to both their brains & their testis?!
Let’s look at a few more metrics from the Ivermectin rat study:
Here’s a diagram which depicts the sperm life cycle, starting from spermatogonia and proceeding through mitosis and then through 2 stages of meiosis (MI, MII) and finally through spermatogenesis to yield spermatozoa.
Let’s look at the differences in abnormal sperm cells by category by treatment group in this series of 9 charts:
Other Pgp inhibitors that enhance ivermectin toxicity include K2, quercetin, hot peppers, curcumin, turmeric, CDB & THC.
Sheep Study Finds Drop In Sperm Motility & Concentration Post-Ivermectin
A Turkish study on Ivermectin’s fertility effects on male sheep by Tanyildizi and Bozkurt also found a stark decrease in sperm motility and concentration after injecting ivermectin (0.2mg/kg) subcutaneously (full report here)
“In this study, the values of sperm motility and concentration were observed to decrease significantly (p<0.01) when compared with the control group.”
Here is a chart of the sperm concentration & sperm volume of the Ivermectin injected sheep vs the levels from the no-Ivermectin control group:
The Smoking Gun: Use In Genocide In Africa/ Central America
In 1974, Kissinger announced the “world population plan of action” under Nixon’s presidency. NSSM 200 is nothing short of an atrocious secret government document talking about the capping of the world’s population at 8 billion. This menacing declaration of genocide was official US government policy and has been declassified in part (Document link)
Mass Ivermectin Administration
According to an article from Merck, they have shipped 4 billion doses of one version of Ivermectin, Mectizan, to people of poor countries:
“The Program reaches more than 400 million people annually; over 4 billion Mectizan [Ivermectin] 3mg tablets have been shipped to endemic countries by Merck since the inception of MDP in 1987.”
According to another Merck article, they claim the total Ivermectin doses donated surpasses 4.4 Billion… with the help of a public-partnership between Merck, the Task Force for Global Health & the WHO.
Here’s a list of all the countries that receive or have received Ivermectin donations from Merck (as per Mectizan Donation Program article):
American Samoa, Angola, Benin, Brazil, Burkina, Faso, Burundi, Cambodia, Cameroon, Central African Republic, Chad, Colombia, Congo, Cook Islands, Côte d’Ivoire, Democratic Republic of the Congo, Ecuador, Egypt, Ethiopia, Fiji, Ghana, Guatemala, Guinea, Guyana, Haiti, India, Indonesia, Kenya, Kiribati, Liberia, Malawi, Malaysia, Mali, Marshall Islands, Mexico, Mozambique, Niger, Nigeria, Niue, Palau, Papua New Guinea, Senegal, Sierra Leone, South Sudan, Sri Lanka, Sudan, São Tomé and Príncipe, Tanzania, Thailand, Timor-Leste, Togo, Tuvalu, Uganda, Vanuatu, Venezuela, Vietnam, Wallis and Futuna & Yemen
See the obvious connection between this group being poisoned by the depopulation agent called “Ivermectin” and Kissinger’s target country list? I hope so.
“The Task Force For Global Health”
So who is this ‘Task Force For Global Health’ shipping all this poisonous ivermectin to poor people around the world for free?
To debate me on ivermectin LIVE on-air, email timtruth@protonmail.com . Try to get your favorite ivermectin-pushing Jim Jones POS to grow some balls and debate me and you’ll see they’re just playing dumb. It’s my contention they are purposefully pushing depopulation agents on us.
I know this article is going to get swarmed with hate, just like my vitamin investigations. Posting content like this leads to a loss of subscribers therefore a loss of revenue. This is why everyone will discuss how bad processed food is but few will discuss processed supplements and processed medicines. I wonder why that is? Why aren’t we allowed to ask, “What ingredients are in this? How are they made? What exactly do these ingredients do when we consume them?”… those seem like reasonable questions to me. After all, most of us read labels before buying a product at the grocery store so why is it taboo to read the label of a health product? Or a miracle cure? Is wanting to know what we are swallowing or injecting really that outrageous? I don’t think so but as I have demonstrated, simply saying, “Hey guys, this product contains hazardous ingredients. Here’s the data from the manufacturer” gets me labeled a shill, a conspiracy theorist and a confused idiot.
However, I’m not here to appease the masses and I have nothing to sell you, 100% of my income comes from donations and subscriptions, so call me whatever you’d like, cancel your account, speak ill of me, whatever you feel is justified as a response to looking at ingredients in a product famous doctors, the CDC, the NIH, Merck and Billy-boy Gates are recommending.
Over the past year, I have been obsessed with researching the foundations for what we assume to be true, yet never questioned. Alarmingly, it seems everything I have looked into is never what we have been told it is (“Vitamins”, Dinosaurs, Satellites FFS!, GeoEngineering, Covid, Covid masks, you name it, it’s probably a lie). So, when my friend
Tim Truth created a video talking about Ivermectin being a fertility reducing poison pushed on us as a cure, I wasn’t surprised but I was very disappointed. The reason for my disappointment was that I never questioned what exactly Ivermectin is or what is in it. I’m not exactly sure why I blindly trusted strangers online for medical advice. I cannot come up with a single good reason, but looking back, I can clearly see the Psychological Operation (PSYOP) ran on the populous, especially with Ivermectin.
When the media came out against Ivermectin, because I don’t trust the media, I got suckered into believing it must be a wonder drug. After all, the guy who invented it won awards, right?! And so many people were saying it cured them! Not only did I blindly trust, I spent hundreds of dollars stocking up, in fear that it might be banned. I wanted to be sure this miracle treatment would be available for my family. I even saved the link to Dr. Stella Immanuel’s website where she will prescribe you Ivermectin (for a fee). (btw, it was embarrassing just to type all of that)
After listening to Tim’s show, I wanted to look into the real history of Ivermectin but there didn’t appear to be any content of this nature available online other than short-and-sweet, sugarcoated summaries on the NIH, CDC and Merck’s websites. Since I am on a mission to discover the foundation of things we assume to be true, I decided to dig into it.
Here’s my research. Hopefully you choose to read it with an open mind, and if not, that’s fine too. If Ivermectin is helping you, FANTASTIC! TAKE IT! I want everyone to do what they feel is right. I want all of us to be happy and healthy. Without further ado, let’s begin:
THE PROBLEM
Every solution starts with a problem and this is how Ivermectin came to be. You see, people living in fertile river valleys in the tropical and Sahel regions of Africa, Yemen, southern Mexico, Guatemala, Ecuador, Colombia, Venezuela, and the Brazilian Amazon were developing one, or more, of the following symptoms:
Let’s condense the list to skin and eye issues. These symptoms would eventually be named River Blindness. The medical term is Onchocerciasis.
River Blindness was such a problem that a super-creepy postage stamp would be created to raise awareness:
THE STUDIES
Nobody knew what was causing River Blindness, so in the late 1800s and early 1900s, it was suggested that perhaps black flies, which live near bodies of water, were causing the health problems (skin and eye issues).
[Keep in mind, this exact timeframe was the beginning of Virus Theory, Germ Theory, Vaccine Theory and what I will call Vitamin Theory. All of these theories are based on Immune System Theory. All of these theories rely on, “your body needs this lab-made product to be healthy”. And all of these theories are all highly profitable, that part is not a theory.]
A handful of scientific experiments were conducted to determine if black flies were the cause of these symptoms. As you read through these studies, keep in mind, this research became the foundation for what would known as Ivermectin:
A document written in 1922 discusses how eight different experiments were ran by different scientists to prove the existence of insect larvae in the bloodstream of humans who were infected with the aforementioned symptoms. All of the experiments produced, “almost completely negative results”. Meaning, nothing had been found in the blood of people deemed to be infected.
In one of those experiments, a scientist examined 2,000 cases (infected people), and only once was he able to locate larvae. In this single instance, the scientist claimed that he squeezed them out of some dudes finger (for real, that’s what the paper states). The document says, he “squeezed the finger powerfully” until it bled. That blood was used for a blood smear and, allegedly, larvae were present. Nobody was able to replicate these results. The scientist himself was unable to duplicate the result. Larvae never appeared in the remaining 1,999 infected people.
In another experiment, 290 men with skin issues were selected. Out of these 290, 24 were investigated further. Although doctors did not locate larvae inside these men they did locate tumors, lots of tumors. More studies of the same nature were conducted which also found tumors. It was then hypothesized that black flies might cause tumors.
Another set of experiments involved two men who were already suffering from the aforementioned symptoms. These men allowed black flies to bite them. The flies were then dissected. Science claimed to have discovered that the infection from the men was present in some, but not all, of the flies that bit them. Science was unable to determine the reason why half of the flies did not contain the infection.
In the three studies that followed, flies were fed something science deemed to be infected then the flies were dissected. The results were the same as the prior study, meaning some flies allegedly had the infection in them while others did not, despite consuming the same infected food.
This evidence somehow confirmed that the health problems (skin and eye issues) were likely caused by larvae. They theorized this larvae was spread from person to person through “repeated bites” of a black fly.
THE FLY BITE STUDIES
The next studies were to prove the larvae, theoretically transmitted through a fly bite, grow inside people and cause illness, which was a key component to the fly bite transmission theory.In this study, two monkeys were given injections of “advanced stage fly larvae” which the scientists claim to have extracted from the heads of dissected flies who were deemed to be carrying the infection. The scientists injected the larvae under the monkeys skin. One monkey received the injection “in the head” and the other received it “in the flank”. As of two months later, neither monkey showed any symptoms of disease. There is no further mention of the larvae.
Because the monkey studies were unsuccessful, scientists switched to using other animals and methods. These new methods involved dorsal fins, removing slices of skin then keeping the skin alive to run wacky tests on it, centrifuging blood samples to try to find larvae, and more … that was when I stopped reading because it was pointless.
After three hours of digging, I am unable to locate a single study that demonstrates a perfectly healthy person who did not have parasites, worms, larvae, nor any form of disease, was bit by a fly which transmitted larvae, causing disease. This is very concerning because it is the foundation for everything that follows. If you can find a normal study that took place on healthy humans and didn’t involve a human injecting another human with anything please share the links.
FIGHTING THE DISEASE
Up until this point, citizens who were deemed to be infected were being fed highly toxic poisons as medicine. These ineffective and deadly chemical compositions were called Diethylcarbamazine and Suramin.
Despite the medicine being labeled a cure, it was not curing anyone, so Science told the citizens that the only way they can save themselves is if they move away from the rivers to prevent the disease. The relocation had devastating impacts on the communities. When they surrendered their natural resource, the river, they were no longer near water, therefore could no easily longer grow food and now had to travel to access water. To make matters worse, the relocation did not stop the disease the flies were causing.
Surprisingly, the repeated poisoning of the river did not stop people from developing skin and eye issues. Want to know why? Don’t you dare say, “because the flies never caused the disease to begin with”, that’s something a conspiracy theorist would say! The correct answer is, history claims,“immigrant flies began to reinvade treated rivers, and some flies developed resistance to the insecticides used by the program.”… so, to recap: feeding the people poisonmedicine didn’t work, moving away from the river didn’t work and poisoning the river over and over didn’t work. People were somehow still developing skin issues and eye issues.
In 1971, a scientist named Satoshi Ōmura traveled from Japan to the US to meet with other scientists including the head of Merck Research Laboratories. He was given money by the NIH and several large pharmaceutical companies ”to search for naturally occurring novel therapeutics”. In 1973, only two years after the meeting and funding, he was contracted by Merck to work for them.
History claims, shortly after the contract was signed, Satoshi took a soil sample from a golf course and it just so happened that this sample contained a new, undiscovered bacteria. This bacteria was said to have killed parasites in soil.
Long story short, Merck created a concoction in a lab, said it was the same as the dirt-bacteria, and it was called Avermectin / Avermectin B1. Ivermectin is a chemically modified derivative of Avermectin B1.
When Ivermectin first went to market it was sold as a parasite medicine for animals. This chemical blend was labeled“25 times more potent” than existing parasite medications.
Merck’s human-drugs division realized that if Ivermectin could enter the human market the profit potential was unfathomable. So, Merck did what it needed to do to demonstrate that this product (recently discovered in that golf course soil sample then produced in a lab with chemicals) was a cure for humans too.
Since science had somehow proven River Blindness was caused by larvae transmitted through repeated bites from a black fly, this was the perfect target market for Merck’s animal product. With the support of the WHO, clinical trials began in 1981, resulting in the approval of Merck’s Ivermectin drug being used in humans. Merck named the human version of the drug Mectizan. (Mectizan was the brand name whereas Ivermectin is the generic drug name, meaning they are they same thing, both of which are derived from lab-made Avermectins, which we are told is the same as the dirt-bacteria discovered by the dude at the golf course, right after the injection of pharmaceutical company funding.)
Ivermectin would become one of Merck’s best selling products of all time. Within 25 years sales would exceeded $1 billion dollars.
Merck stated that because of the financial success of their animal parasite drug, they were able to afford to do good in the world by donating millions of doses per year to the people living in regions that have infected flies. Just in 2006, Merck donated over 69 million doses.
Now that you know the real history of Ivermectin, lets take a deeper look at what exactly it is.
HOW IT’S MADE
History claims the bacteria in the soil discovered by Satoshi Ōmura was Streptomyces avermitilis (S. avermitilis). Just like we learned in my Pfizer Cheese article and WTF! How Vitamins are Made piece, this stuff they are selling us isn’t natural. They are not bottling golf course soil bacteria. In the case of Vitamins and Ivermectin, what we are purchasing is being made in a lab through microbial fermentation. Here’s a brief overview of how Avermectins are mass produced:
S. avermitilis41445 is the bacteria strain you start with:
yeast extract malt extract glucose (YMG) is fed to the bacteria to grow it:
All of those ingredients are going to eventually result in the production of Avermectins, which they call industrially derived mutants. But get this…
IVERMECTIN: DEADLY INSECTICIDE
These lab-made GMO Avermectins, created from mutant bacteria (Streptomyces avrrmitillis) are so toxic that they kill Arthropods.
Arthropods areinvertebrates with jointed legs, including lobsters, crabs, scorpions, bees, butterflies, spiders and more.
They make up about 84% of all animals on Earth.
Arthropods have a major role in maintaining ecosystems as pollinators, recyclers of nutrients, scavengers and food for other animals. But if you want to kill them, Ivermectin works great! Need to massacre some blue crabs? Get out the Ivermectin:
Yep, Ivermectin is an excellent poison to slaughter these dudes:
One must ask, how much of the 84% OF ALL CREATURES IN THE WORLD can this substance kill?
Because of its effectiveness in demolishing Arthropods, Avermectin B1 / Abamectin / Ivermectin is used as an insecticide.
And only 0.05% of it is needed to kill life:
It is the main active ingredient in cockroach killer:
Ivermectin was registered as Fire Ant Killer with the EPA back in the 1980s and has been used as an ant killer ever since.
And to kill the alleged parasites in our bloodstream (transmitted from fly bites), this poison has to be in our blood. I know people are going to say, “It’s only toxic to insects! It doesn’t hurt people!“. I find it really strange how often people say this now. Vitamin D IS Rat Poison, but they tell me it doesn’t hurt people.Vitamin B3 IS insecticide that contaminated a city, but that doesn’t hurt people either. K2 IS pesticide and rat poison, but it doesn’t hurt people. Vitamin B is made from cyanide, but it’s a special type of cyanide that doesn’t hurt people (also developed by Merck). Ivermectin IS insecticide, but it doesn’t hurt people. Why are all these vitamins and miracle cures literal poison that kills life? And what do all of these healthy poisons have in common? Merck, Bill Gates, the United Nations and pals give them away for free to help people… Does nobody else find that fact to be eyebrow-raising?…
And I know someone is going to say, “Everything is poison! It’s the dose that makes it safe!” – NO, everything is not poison. Nobody got diabetes from eating too many apples. Nobody had a heart attack from too much broccoli. Hell, nobody has ever become obese from pounding bags of carrots all day. Not everything is poison. And nobody ever died from drinking too much clean water either. I might write a post just on that because it is the most common rebuttal and it’s simply false.
For the sake of being a thorough journalist, just to be 100% sure this product is only poison for 84% of life on earth but not humans, let’s check out the manufacturers safety data sheets for Ivermectin:
THE SAFETY DATA SHEETS
A Manufacturers Safety Data Sheet (MSDS / SDS) is what is provided by the company who makes the chemical product. The MSDS outlines how to handle the product, how to dispose of it without damaging the environment, what to do if it is inhaled or swallowed, if employees need to wear respirators around it, health issues that result from the product, etc. You can’t get any closer to the truth than by looking at the data directly from the company who makes the product because, for legal reasons, the manufacturer cannot lie or sugarcoat Safety Data Sheets.
In Section 2 of the MSDS we see this is a very toxic product. Category 1 means it can inflict permanent damage with a single exposure.Category 2 means it can inflict damage with repeated or prolonged exposure. We also learn that it attacks the Central Nervous System:
An attack on the Central Nervous System (CNS) can result in a wide range of horrible side effects including vision loss / blindness, infections (such as meningitis, carpal tunnel syndrome), paralysis, severe headaches, confusion, seizures, weakness, Guillain-Barré Syndrome, stroke, and genetic predisposition. But that’s not all. A CNS attack can also result in a plethora of skin issues including Skin Discoloration (Ataxia-telangiectasia and Tuberous sclerosis complex). This is Tuberous sclerosis complex, a side effect of a Central Nervous System attack:
This is River Blindness, caused by larvae:
Tuberous sclerosis complex rash, a side effect of a Central Nervous System attack:
River Blindness caused by larvae:
In Section 3 of the Veterinary MSDS for Ivermectin we are provided with a list of chemicals in the product:
I don’t want to dive into all of these, but here’s a couple:
Propylene Glycol (“PG”) removes water, therefore it is dumped into everything to act as a preservative. It is also used as a flavoring agent, a dough-strengthener and an emulsifier. You will find this chemical in pharmaceuticals, foods, and personal care products. As with all chemicals, it too is toxic and this product specifically causes kidney injury.
Interestingly, PG can also cause “sepsis-like syndrome”. According to the WHO, spesis is caused by bacteria or parasites.
So, 49% of each dose of animal Ivermectin can cause the identical problems it is taken to stop or prevent. But no need to worry, that’s Ivermectin made for animals, not people. The FDA has classified PG as generally safe for humans to eat:
Butanone is another ingredient in animal Ivermectin. It is also used in plastic welding because it dissolves plastic. It is used in dry erase markers to make the erasable dye… and it is great for healthy medicines for animals and humans.
Butanone accounts for 10% of the animal product and it too is hugely toxic. In fact, it is so toxic that as of 2010, the United States Environmental Protection Agency (EPA) was forced to add butanone to its dangerous, toxic chemicals list because of the neuropsychological effects it causesdue to being rapidly absorbed through undamaged skin and lungs. This dangerous chemical also contributes to the formation of ground-level ozone, which is toxic, even in low concentrations. But people are going to say, “This is for animals, not humans!”. Ok, let’s make sure that is true…
Next we will look at Fisher’s MSDS for Ivermectin. This Safety Data Sheet specifies to only use it in a lab and not to use it a “food, drug, pesticide” or to kill anything.
The reason I show you this is because, even though this Ivermectin states not to use it as food, medicine or pesticide, it has the exact same hazard classifications at the veterinary use Ivermectin:
Additionally, you will see that this product is labeled hazardous. It also damages fertility and can harm an unborn baby. In fact, it is a Category 1A, which means “known human reproductivetoxicant” (meaning, it is not suspected to cause harm, it does cause harm):
In the image above, we also see that it is Fatal if Swallowed.
Here we see that if it is ingested a poison center should be called immediately. We also learn it is “very toxic to aquatic life”.
I know the response is going to be, “But that says not to use as medicine! Show me a safety data sheet for the medicine version or you’re a shill!” – Ok, I will do you one better than that.
I went on a mission to find the best of the best of the absolute best, most-purest-ever Ivermectin. I was able to locate a couple USP grade Ivermectin’s that exceed pharmaceutical standards. These are as pure and clean as it is ever going to get!
Here it is, at the hefty price of $144 for only one kilo (2 pounds)!
As we can see from the image above, this Ivermectin is a mixture of two Avermectins.
The good news is, although this product is considered Hazardous, it is a Category 2 and 3 Hazard. This means it might cause permanent damage with repeated or prolonged use and it is suspected of causing harm but it is not guaranteed that it will cause harm, so that’s good.
If we scroll down to Label Elements we see the same warnings as the other products:
And the skull graphic is required, because it is deadly.
To be more specific the skull pictogram means Acute Toxicity. The legal definition is, “Acute toxicity means that exposure to a single dose of the chemical may be toxic or fatal if inhaled or swallowed, or if it comes into contact with the skin.”
Oh look, it also can affect the central nervous system, just like the other Ivermectins:
When this product ships it must ship as Toxic Solids and Hazardous Waste:
In Europe, three additional Hazard Classes must be added in addition to a second skull:
To recap: the animal version of Ivermectin is a hazardous toxin, the lab-use-only version is a hazardous toxin and even if you spend the money to buy the absolute best, top shelf, cleanest-ever Ivermectin, it is still a hazardous poison that is “very toxic if swallowed”.
MERCK, THE EPA AND THE GOVERNMENT
Remember how, on the purest-of-pure Ivermectin USP grade MSDS, it says Ivermectin is a mixture of Avermectins (mutant bacteria stuff made in a lab):
I located a 2008 document from the Canadian Government website, OEHHA.ca.gov. In the document they discuss the US government labeling Avermectin B1 a reproductive toxin back in 1994.
Because Merck was making Ivermectin using Avermectin, this same document features a response from Merck regarding the safety of Ivermectin. Quote:
“Merck states that primates are less sensitive to the acute effects of abamectin and its analog, ivermectin, than rodents. The commenter implies that because humans are primates, abamectin should be less toxic in humans than in rodents.” … “Abamectin interferes with gamma-aminobutyric acid (GABA) transmission and, as such, produces neurotoxic clinical signs such as tremors, ataxia, convulsions, or comathat are more severe in rodents and dogs than primates.”… ”There are no developmental studies with abamectin in primates. Therefore, EPA believes that the rodent studies cited in the proposed rule provide sufficient evidence that abamectin can reasonably be anticipated to cause developmental toxicity in humans.” – well that’s interesting, eh?
IVERMECTIN AND FERTILITY REDUCTION
Tim Truth did a deep dive into Ivermectin and how it plummets fertility. While you listen to this, remember that everything is based on the premise that a black fly transmits larvae that causes skin issues and blindess. (58 minute video. If it won’t play, audio-only version is below. If that won’t play either, watch on Bitchute)
Ivermectin Cell & DNA Toxicity Study By Zhang Et Al
In a study called ‘Ivermectin Confers Its Cytotoxic Effects by Inducing AMPK/mTOR-mediated Autophagy and DNA2 Damage’ Zhang Et Al (full report here)
“Ivermectin has significant ability to induce DNA oxidative damage and enhance autophagy in HeLa cells”
“The accumulation of IVM in animal tissues and the excretion of urine and feces in the environment is the major source of potential toxicity… Human consumption of meat or milk contaminated with livestock can result in exposure to high levels of IVM exposure.”
“As expected, we found that IVM can induce oxidative double-stranded damage in HeLa cells, indicating that IVM has potential genotoxicity to human health. In addition, we observed the formation of LC3-B in HeLa cells, the accumulation of Beclin1, the degradation of p62 and the activation of the AMPK/mTOR signal transduction pathway.”
“We conclude that IVM produces genotoxicity and cytotoxicity by inducing DNA damage and AMPK/mTOR-mediated autophagy, thereby posing a potential risk to human health.”
“As shown in Fig. 1A, the cell clone formation rate decreased gradually with the increase of IVM concentration after 6 h of drug administration.”
Ivermectin Genotoxicity And Carcinogenicity Observed With Fruit Flies
In a study called ‘Genotoxicity and carcinogenicity of ivermectin and amoxicillin in vivo systems’ by Aparecida de Sousa et al (full report here),
“The results revealed that IVM increased the frequency of epithelial tumor in D. melanogaster considering all evaluated concentrations”
“Findings showed an increase in the frequency of micronuclei in T. pallida treated with 11.42, 22.84 and 45.68 x 10 −5 mM of IVM. We conclude that chronic exposure to IVM is directly associated with events resulting from genetic instability (genotoxicity and carcinogenicity).”
Ivermectin appears to drastically reduce survival rate of fly progenies as the dose is increased:
Frequency Of Tumor Clones By IVM Treatment Dosage:
“It was observed a dose-dependence in the frequency of MN in T. pallida considering the highest concentrations (11.42, 22.84 and 45.68 × 10−5 mM) differing statistically (p ≤ 0.05) from the negative control, evidencing a genotoxic effect of IVM”
“The results observed in D. melanogaster and T. pallida showed that IVM can increase the damage in the genetic material, leading to genetic instability.”
Why fruit flies? The authors explain:
“In D. melanogaster, the test for the detection of epithelial tumor (ETT) represents one of the most promising alternatives to evaluate and identify possible carcinogens (Nepomuceno, 2015) … This test has also been used to verify carcinogenic events of different substances (Orsolin et al., 2012; Morais et al., 2018; Naves et al., 2018).”
Ivermectin Mutagenicity In Swiss Albino Mice
In a study titled ‘The mutagenic effects of ivermectin in germinal cells and serum protein of the mouse’ by Sweify et al
“Ivermectin… is extremely toxic to fish and aquatic life. Some animals showed reduction in the fertility, the number of variable fetuses and sperm count following treatment with (IVM).”
“Analysis of the treated samples revealed significant increase in meiotic aberrations, 33.83% vs 5.8% for the control (P < 0.001)… These findings supports the mutagenicity of IVM”
“Effects of ivermectin on spermatocyte chromosomes: … spermatocytes of the treated samples revealed significant increase in chromosome aberrations over the control values”
“The present observations pointed to the mutagenic effects of IVM. The frequency of translocation is significantly higher than that found in the control samples”
Ivermectin Vs Human Neuroblastoma SH-SY5Y Study
In a study called ‘Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy’ by Zhange et al
“The results show that IVM treatment (2.5–15 μM) for 24 h could induce dose-dependent cell death in SH-SY5Y cells. Compared to the control, IVM treatment significantly promoted the production of ROS, mitochondrial dysfunction, and cell apoptosis. IVM treatment also promoted mitophagy and autophagy, which were charactered by the decreased expression of phosphorylation (p)-Akt and p-mTOR proteins, increased expression of LC3II, Beclin1, ATG5, PINK, and Pakin1 proteins and autophagosome formation… our results reveal that IVM could induce autophagy and apoptotic cell death in SH-SY5Y cells”
“IVM-induced cytotoxicity is dose- and time-dependent. At 6 h and 12 h, IVM treatment at 15 μM significantly decreased the cell viabilities to 44.3% and 35.6% (both p < 0.01), respectively; at 24 h, IVM treatment at 0.625, 1.25, 2.5, 5, 7.5, 10, and 15 μM decreased the cell activities to 98.5%, 92.4%, 81.9% (p < 0.01), 70.2% (p < 0.01), 51.3% (p < 0.01 ), 37.6% (p < 0.01), and 23.8% (p < 0.01) (Figure 1), respectively. Correspondingly, marked cell morphology changes, including a spindle-like cell body, shrinkage, and dendrite fragmentation in high concentrations of IVM (at 7.5, 10, and 15 μM for 24 h, respectively) were also detected”
https://www.mdpi.com/2076-3921/11/5/908
https://www.mdpi.com/2076-3921/11/5/908
Ivermectin Vs Buffalo Peripheral Lymphocyte Cells
In a paper called ‘Antimutagenic Activity of Some Natural supplements on Ivermectin genotoxicity in Lymphocytes of Buffalo’ by El-makawy et al,
Cell Abnormalities
# Per 10,000 Cells Examined, Blue line = Control Levels
Structural Chromosomal Aberrations Observed:
“Ivermectin induced dose dependent significantly increase in the number of binucleated lymphocytes with micronuclei and also the frequencies of total chromosomal aberrations”
“In addition, the numbers of binucleated lymphocytes showed dose dependent decrease than control. These results revealed that the drug has a cytotoxic effect on the number of cell divisions. As the micronuclei are small chromatin-containing bodies arising from chromosome fragmentation by breaks or deletion, the results of MN formation confirmed our results of chromosomal aberrations indicating the clastogenic effects of ivermectin.”
In Vivo Ivermectin Vs Mice Bone Marrow Study
In a study called ‘The cytogenetic potential of ivermectin on bone marrow cells of mice in vivo’ from Sweify et al:
“IVM induced high level of chromosome aberrations in somatic cells, as it is ascertained by chromosome aberration assay and micronuclei production in bone marrow cells. This study revealed high clastogenic and genotoxic potential of IVM on mice”
Experiment 1: Single Injection Of Ivermectin
“The Table contains also the different types of chromosomal aberrations recorded in the examined cells. A single i.p. injection of ivermectin resulted in a significant (P≤0.001) increase in percentage of aberrant cells”
Here are the different chromosomal aberrations that were tracked after the invermectin injection. The transparent horizontal lines are the control levels:
Experiment 2: Two Injections Of Ivermectin
“It is clear from the Table (II) that injection with ivermectin induced high significant increase in the frequency of the damaged cells allover the examined periods (P≤0.001).”
Here are the different chromosomal aberrations that were tracked after the second invermectin injection. The transparent horizontal lines are the control levels:
Study of Genotoxic and Cytotoxic Effects Of Ivermectin In Chinese Hamster Ovary Cells In Vitro
In a study called ‘In vitro genotoxic and cytotoxic effects of ivermectin… on Chinese hamster ovary (CHO K1 ) cells’ by Molinari et all, they found that Ivermectin caused DNA-strand breaks in Chinese hamster ovary (CHO(KI)) cells. (Full article)
Here’s a chart of mitotic index (MI) and mitotic index factor (f) for each of the lesser doses before the “complete cellular death” seen in doses 50µm/ml. The transparent horizontal lines are the control group baseline
Decrease in mitotic index typically indicates genotoxicity. (Sweify, 2019)
“IVM exerted a cytotoxic effect of CHO cells within the 25.0–250.0 μg/ml concentration-range”
“Highest [IVM] concentrations (50.0–250.0 μg/ml) resulted in cellular cytotoxicity clearly revealed by delaying the cell-cycle progression, decreasing the mitotic activity, and inhibiting cell-growth. It is worth mentioning that both chemicals induced DNA-strand breaks revealed by the comet assay”
“A brief 80 min pulse-treatment of 5.0–50.0 μg/ml of IVM or 25.0 and 50.0 μg/ml of ivomec® , resulted in a manifest level of single DNA-strand break induction.”
O’Conner Ivermectin Rat Carcinogenicity Study
In an article called ‘Increased Pathology Incidence in the Forestomach of Rats Maintained on a Diet Containing Ivermectin and Given a Single Dose of N-Methyl-N1-Nitro-N-Nitrosoguanidine’ by O’Conner et al, they observed additional cancers in mice with a small amount (2 ppm) of ivermectin in their diet given a dose of a carcinogen called N-Methyl-N1-Nitro-N-Nitrosoguanidine. From the abstract:
“No tumors or pathological lesions were observed in the forestomach of the control animals or those given ivermectin alone. However, compared to animals receiving MNNG alone, rats maintained on a diet containing ivermectin (2 ppm) and given MNNG… showed an increased number of neoplasms (9/26 vs 3/18; p = 0.30) and a statistically significant fourfold increase in the number of pathological lesions (18/26 vs 3/18; p = 0.002), which include preneoplasia in the forestomach. In all cases, the pathological lesions were more severe in the animals receiving ivermectin and MNNG, compared to those receiving MNNG alone.”
Study of Genotoxic and Cytotoxic Effects Of Ivermectin In Mosquito Cells In Vivo
In a study called ‘Genotoxic and cytotoxic in vitro evaluation of ivermectin… on Aedes albopictus larvae (CCL-126™) cells’ (Full paper):
“IVM… induced DNA-strand breaks enhancing both slightly damaged and damaged cells at 25–50 μg/ml IVM”
“Cytotoxicity was observed at concentrations higher than 25 μg/ml IVM… [Ivermectin] exerted a delay in CCP and a reduction in PRI when 25.0 μg/ml was employed whereas cytotoxicity was observed at higher concentration than 50.0 μg/ml.”
“A marked reduction of about 98% … of MI [mitotic index] compared to controls was noted with 25 μg/ml of IVM”
“NR and MTT assays revealed that [IVM] induced a cell growth inhibition within the 1–250 μg/ml concentration range”
“Data indicated that IVM exerts both genotoxicity and cytotoxicity in insect cells [A. albopictus larvae CCL-126 cells] in vitro”
This chart shows the percentage of undamaged, slightly damaged & damaged cells with the addition of Ivermectin (measured in μg/ml). The transparent horizontal lines are the control levels.
Decrease in mitotic index typically indicates genotoxicity. (Sweify, 2019)
Why insect cells? The authors’ address this:
“It was demonstrated that among insects, mosquito cells cultures provide a useful in vitro system for studying deleterious effects induced by xenobiotics (Mukherjee et al. 1986; Bolza ́n et al. 1998, 2000). Investigations demonstrated that DNA damage induced by different chemicals was found to be less extensive and repaired more efficiently in Aedes albopictus larvae cell lines compared to Chinese hamster ovary (CHO-K1) cells”
Ivermectin In Cebu Brahman Cows
In a paper called ‘Comet assay to determine genetic damage by the use of ivermectin in zebu cows’
“The values of classification of comets indicate cells with high levels of damage (grade 3: cells with high damage). The rate of DNA damage of the treatment to 1% to 3.15% was significant… The results obtained in this study demonstrate the likely genotoxic potential of the use of IVM in cattle.”
“Regardless of the IVM concentration, the presence of nuclei with DNA migration (Figure 1a and b) was observed at a percentage greater than 75% in all cells observed per plaque, demonstrating the ability of the IVM compound to produce simple chain breaks in the DNA molecule.”
The Comet classification describes how. All of the control group (no treatment) measure 0 on the comet scale. Here are the Results for the IVM treated cows:
Grade 3 = cells with high damage
“The results found in the present study constitute concrete evidence for the induction of genomic damage as exerted by IVM, using the comet assay methodology”
“Ivermectin (20 pg/mL) decreased glucose utilization in IB-RS-2 cells in 11, 30, and 31%, respectively, after 24,48 and 72 h”
Ivermectin Vs Tadpole DNA
In a study called ‘Genotoxicity of Three Avermectins on Polypedates megacephalus Tadpoles Using the Comet Assay’ by Geng et al, some very concerning findings were noted in relation to Ivermectin’s “genotoxic effects at relatively low concentrations” in Tadpoles.
The first chart shows a dose-dependent decline in cell viability as IVM dosing increases:
“Our results showed clearly that avermectins caused dose dependent DNA damage on amphibian tadpoles… The three avermectins increased the DNA damage observed in the tadpoles in a dose-responsive manner. There were strong linear correlations between the DNA damages and the concentrations of the three test substances (Figure 2). The cellular distributions of DNA damages in tadpoles are shown in Figure 3. Of the tadpoles treated with increasing concentrations of the three test substances, higher proportions of cells had greater amount of DNA damage than those of the negative control”
This chart shows a dose-dependent increase in DNA damage as IVM dosing increases:
“According to these results above and our finding that avermectins can cause DNA damage in tadpoles at the concentrations below the recommended applied levels (Xu et al., 2010), we consider it possible that avermectins are carcinogenic, and confirm it has the negative impact on the development of tadpoles”
Ivermectin And Pig Kidney Cells
In a study entitled ‘Toxicity Assessment of the Antiparasitic Ivermectin’ by Rodrigues et al, the researchers exposed pig kidney cells to ivermectin at different levels and measured the rates of cell death (Full article)
“Our data show that ivermectin inhibited cell growth (Fig. 1). This effect was time and dose dependent, and ranged from 38 to 84% after 72 h in cells treated with 2-20 pg/mL; at the dosage of 40 pg/mL, cell death occurred within 24 h.”
“Ivermectin (20 pg/mL) decreased protein synthesis and glucose utilization.”
“Protein synthesis is inhibited in a continuous way in the cells exposed to ivermectin (20 pg/mL). When compared to the control cultures, the protein of treated cells is 13,24, and 28% less, respectively, after 24, 48, and 72 h.”
